It may come as a surprise but mice, rats, squirrels, and beavers are some of the few animals that cannot vomit. Though a lucky trait, it becomes a disadvantage for drug testing where vomiting is a potential side effect and it cannot be detected in any of these rodents. Their bodies have a barrier between their stomach and esophagus that prevents them from vomiting. Additionally, their senses of taste and smell make it unnecessary since they have a strong memory for a sickening substance and will avoid it for years or even their whole lives. A 2013 study discovered that “an absent brainstem neurological component is the most likely cause” of their inability to vomit. While humans are not exposed to piles of rodent vomit due to this fact, drugs tested on rodents turn out to be a waste of millions of dollars when humans cannot handle the dosage requirements. Testing on dogs and cats is not practical for most researchers, leaving the shrew as a rodent-like mammal that researchers use for testing since it can vomit.
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