Discover the Truth: Harvard Analysis Reveals Limited Effectiveness of Widely Used Anxiety Medication on 16 Million Americans

By Alexa Lardieri U.S. Deputy Health Editor Dailymail.Com

17:33 24 Oct 2023, updated 17:56 24 Oct 2023

  • Studies reviewing Xanax had bias that inflated efficacy results by 40 percent
  • Researchers looked at five studies and found only one showed actual positives
  • READ MORE: Six little-known signs you are suffering from anxiety


It’s known to be addictive, harsh on the body and risky for overdoses – and now scientists say Xanax might not even be that effective.

Researchers from Harvard University and Oregon Health & Science University re-reviewed trials and studies that looked at Xanax’s efficacy in treating panic disorder.

They found several examples of ‘publication bias’ that exaggerated how positive results were.



The researchers – including a former reviewer for the US Food and Drug Administration (FDA) – concluded while the drug was still more effective than a placebo, publications inflated the drug’s efficacy by approximately 40 percent.

Xanax, also known as alprazolam, was approved by the FDA in 1981 and is in the class of benzodiazepines, a group of depressant drugs used to relieve anxiety
Of the five studies reviewed by researchers, three were presented as positive. However, when the FDA reviewed the studies, only one was deemed positive

Publication bias is the failure to publish the results of a study on the basis of the direction or strength of the study findings.

It happens when the outcome of research influences the decision to publish findings. However, only publishing results that show a significant finding upsets the balance of findings in favor of positive results.

Senior author Dr Erick Turner, professor of psychiatry and former FDA reviewer said: ‘Our study throws some cold water on the efficacy of this drug. It shows it may be less effective than people have assumed.’

The study analyzed published and unpublished data from five clinical trials reviewed by the FDA for Xanax for the treatment of panic disorder, an anxiety disorder where you regularly have sudden attacks of panic or fear.

Of the five trials reviewed, only three of them had been published and researchers deemed only one had positive findings.

Similarly, when the FDA reviewed the trials, only one of them was deemed positive and the other four were classified as ‘failed on face.’

Of the four not-positive trials, researchers found two were published conveying a positive outcome and the other two were not published at all.

The studies were conducted between 1986 and 1989 (not positive), 1988 and 1990 (positive), 1994 and 1995 (not positive) and two took place between 1990 and 1991 (each not positive).

Anti-anxiety drugs can interfere with a person’s neurons and increase their risk of cognitive decline later in life, study finds

Using anti-anxiety drugs may put someone at significant risk of developing cognitive decline later in life and scientists may have finally discovered why.

Xanax, also known as alprazolam, was approved by the FDA in 1981 and is in the class of benzodiazepines, a group of depressant drugs used to relieve anxiety, the most prevalent mental health condition in the US – affecting approximately 40 million adults.

Other common drugs in this class include Valium, Klonopin, and Ativan.

Despite Xanax’s wide use, there are potentially serious side effects.

People taking the drug may experience changes in appetite, nausea, dizziness, sleepiness, changes in sex drive, and irritability.

They may also experience out of control actions, loss of leg control, numbness in hands or feet, decreased awareness, and an unsteady walk.

Additionally, a study from 2022 found anti-anxiety medications may impact a person’s brain cells and neurons, putting them at a higher

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