Canadian researchers believe that a combination of exercise and brain training can delay the onset of dementia and potentially improve cognition in older adults with mild cognitive impairment (MCI). A multi-city clinical trial demonstrated that the combined effect of exercise and cognitive training is greater than the sum of its parts. Lead researcher Manuel Montero-Odasso is optimistic about the results, stating that the improvement in cognitive function is significant and comparable to the improvement seen in recent drug trials for cognitive impairment.
The trial utilized the ADAS-Cog scale, which measures the severity of cognitive symptoms of dementia through various criteria. The assessment was conducted at the beginning of the trial and at the sixth-month mark, with the scores used to determine improvements. The results showed a positive impact on memory, attention, word recognition, and executive function.
Previous research focused on simultaneous exercise and cognitive training, but the results were inconclusive. Montero-Odasso theorizes that combining exercise and cognitive training in a specific order improves blood circulation to the brain, enhancing its receptivity to training.
While the exact cognitive training used in the trial is not publicly available, Montero-Odasso suggests that any form of exercise and mental stimulation is better than nothing. He recommends engaging in physical activity at least three days a week for at least 40 minutes, with an intensity that raises the heart rate by 20%. Following exercise, participants should engage in a mental activity, such as playing chess, to keep the mind active.
The study involved 175 Canadian adults aged 65 to 84 years, split into five groups to compare the effects of exercise, cognitive training, and vitamin D. Cognitive training involved a cloud program on an iPad that focused on attention and memory, gradually increasing in difficulty. Sham cognitive training involved tasks like searching for travel information online. The study found no clinical impact from vitamin D, but Montero-Odasso attributes this to the participants already having high levels of vitamin D.
The next phase of trials, called Synergic-2, will involve virtual, at-home interventions for 550 participants with MCI. Those interested in participating can contact the study team. Overall, the findings highlight the potential benefits of exercise and cognitive training in delaying dementia and improving cognitive function in older adults with MCI.
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