Ginger could play a critical role in controlling inflammation for individuals with autoimmune diseases, according to a recent study conducted by researchers from the University of Michigan and the University of Colorado School of Medicine. The study focused on the impact of ginger supplements on neutrophils, a type of white blood cell. The findings suggest that ginger supplements may also be beneficial in treating people with COVID-19. The researchers were particularly interested in a type of immune response called neutrophil extracellular trap (NET) formation, which is linked to inflammation associated with autoimmune diseases.
NETs are microscopic structures that contribute to inflammation and clotting, exacerbating autoimmune diseases like lupus, antiphospholipid syndrome, and rheumatoid arthritis. However, the study found that ginger consumption made neutrophils more resistant to NETosis in healthy individuals. This is significant because neutrophils are often abnormally overactive in many diseases.
A clinical trial conducted by the research team revealed that daily intake of a ginger supplement for seven days increased the levels of a chemical called cAMP in neutrophils. These elevated cAMP levels inhibited NETosis in response to disease-related stimuli. The researchers believe this study provides evidence for the biological mechanism behind ginger’s anti-inflammatory properties in people.
Given that many individuals with inflammatory conditions are interested in natural supplements, the researchers hope that the evidence about ginger’s benefits will encourage healthcare providers and patients to discuss its use in managing symptoms. The team plans to use the study to secure funding for clinical trials of ginger in patients with autoimmune and inflammatory diseases where neutrophils are overactive, including lupus, rheumatoid arthritis, antiphospholipid syndrome, and even COVID-19.
According to Professor Jason Knight from the University of Michigan, there are few natural supplements or prescription medications known to combat overactive neutrophils. He believes that ginger could complement existing treatment programs and help relieve symptoms in a more strategic and personalized manner. The researchers aim to unlock funding for clinical trials to further explore the potential benefits of ginger in autoimmune and inflammatory diseases.
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