According to researchers, a groundbreaking scientific discovery may hold the key to reversing brain aging. Scientists at the University of California, San Francisco (UCSF) and the University of Queensland in Australia have found that the protein PF4, naturally found in the blood, can restore cognitive function in older mice and enhance brain function in young mice. The study showed that when given PF4, two-year-old mice, which are equivalent to 70-year-old humans, exhibited the cognitive abilities of individuals in their 30s or 40s.
PF4, a blood cell produced by platelets, works by calming the immune system and reducing inflammation, which are significant contributors to brain and body aging. The researchers also discovered that blood transfusion from younger mice, exercise, and the klotho gene involved in the aging process can introduce more PF4 into the body.
Saul Villeda, associate director of the UCSF Bakar Aging Research Institute and senior author of the study, explains that “Young blood, klotho, and exercise can somehow tell your brain, ‘Hey, improve your function.’ With PF4, we’re starting to understand the vocabulary behind this rejuvenation.” Dr. Dena Dubal, a professor of neurology at UCSF, adds that the convergence of three separate interventions on platelet factors emphasizes the validity and reproducibility of this biology, and suggests that it is time to explore platelet factors in brain health and cognitive enhancement.
While the findings are promising, it is important to note that the research is still in its preliminary stages and needs to be replicated in humans. The potential side effects of suppressing the immune system to prevent aging, such as compromising the body’s ability to fight diseases, also require further investigation.
The study discovered that injecting PF4 into older animals restored brain function by decreasing inflammation and increasing plasticity, ultimately improving cognition and memory. In the second study, researchers found that a shot of klotho increased PF4 production, leading to enhanced memory formation and new connections in the brain. The study examining exercise revealed that physical activity stimulates platelets to release PF4 into the bloodstream.
Tara Walker, lead study author and professor of neuroscience at the University of Queensland, emphasizes the importance of pharmacological intervention for individuals who cannot engage in physical exercise due to health conditions or age-related mobility issues. By targeting platelets, it may be possible to promote neurogenesis, enhance cognition, and counteract age-related cognitive decline.
The research papers detailing these findings were published in the journals Nature, Nature Aging, and Nature Communications. However, further research is needed to fully understand the implications and applicability of these discoveries in humans.
Denial of responsibility! VigourTimes is an automatic aggregator of Global media. In each content, the hyperlink to the primary source is specified. All trademarks belong to their rightful owners, and all materials to their authors. For any complaint, please reach us at – [email protected]. We will take necessary action within 24 hours.
