Osaka University scientists generate bi-parental mice using gene editing technology

Scientists have achieved the creation of mice with two fathers by developing eggs from male cells. This breakthrough in research has the potential to lead to radical developments in human reproduction. The technique could allow both fathers to have children related to them and provide a treatment method for a type of infertility in women.

Nevertheless, researchers caution that there would need to be much more exploration and ethical analysis conducted before applying the approach to humans. Prof Katsuhiko Hayashi from Osaka University unveiled his research findings – which are not yet published – to the International Summit on Human Genome Editing at the Francis Crick Institute in London.

The research process involved creating a stem cell from a skin cell of a male mouse and then deleting the Y chromosome while duplicating the X chromosome, enabling it to mature into an egg. Only seven pups were born from 600 implant attempts; however, they grew into healthy adults and had offspring of their own.

It is not the first time related research has been conducted. In 2018, researchers at the Chinese Academy of Science produced mice from two fathers successfully, but the pups were unhealthy and died soon after. Prof Hayashi is working on developing fertility treatments and believes that his work could be available for humans in the next decade. However, he pointed out that there are many problems related to the egg’s quality in mice. Therefore, before it may be regarded as a fertility treatment, the issues must be addressed, which could take a long time.

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