NFL Thanksgiving Games: Predictions, Schedule, Injuries, and Fantasy Picks

NFL Nation: Barry Sanders is impressed by the Lions
Hall of Famer Barry Sanders chats with Pat McAfee about the Lions’ potential as contenders in the NFC. Get ready for Week 12 in the 2023 NFL season with three great Thanksgiving Day matchups and some key insights on each game from our NFL Nation reporters. Plus, there are bold predictions, significant stats, betting nuggets, and game projections to help you prepare for a loaded Thursday afternoon of NFL football. Everything you need to know is right here in one spot!

Jump to a matchup: GB-DET | WSH-DAL | SF-SEA

Matchup #1: Detroit Lions vs. Green Bay Packers
Start Time: 12:30 p.m. ET
Spread: DET -7.5 (46.5)

Injuries: Packers | Lions
Matchup to watch: Aaron Rodgers vs. Detroit’s defense

Bold prediction: The Lions will not pick off Packers quarterback Jordan Love.

Stats to know: Lions quarterback Jared Goff has an impressive record against the Packers.

X factor: Packers cornerback Keisean Nixon. He’s a key factor in Green Bay’s defense.

Fantasy insight: Jayden Reed could play a significant role for the Packers in the absence of Aaron Jones.

Betting nugget: The Lions are 11-1 against the spread (ATS) in their past 12 division games.

Final score predictions: The experts say Lions 34, Packers 21

FPI prediction: Detroit will win by an average of 4.8 points.

Matchup #2: Washington Commanders vs. Dallas Cowboys
Start Time: 4:30 p.m. ET
Spread: DAL -11 (48.5)

Injuries: Commanders | Cowboys
Matchup to watch: Dak Prescott vs. Washington’s defense

Bold prediction: Dallas receiver CeeDee Lamb will have a big game against Washington.

Stats to know: Commanders quarterback Sam Howell has been sacked a league-high 51 times this season.

X factor: Cowboys cornerback DaRon Bland. He’s tied for the NFL record with four pick-sixes.

Fantasy insight: Cowboys’ CeeDee Lamb is expected to have a big game on Thanksgiving.

Betting nugget: The Cowboys are undefeated as double-digit favorites on Thanksgiving.

Final score predictions: The experts say Cowboys 34, Commanders 31

FPI prediction: Dallas will win by an average of 13.9 points.

Matchup #3: San Francisco 49ers vs. Seattle Seahawks
Start Time: 8:20 p.m. ET
Spread: SF -7 (43.5)

Injuries: Seahawks | 49ers
Matchup to watch: Geno Smith vs. San Francisco’s defense

Bold prediction: Niners defensive end Nick Bosa will have a big game with three sacks.

Stats to know: San Francisco quarterback Brock Purdy has thrown three touchdown passes in each of his past two games.

X factor: Seattle’s offensive line and San Francisco’s defensive line.

Fantasy insight: Keep an eye on the Seahawks’ rushing game due to recent injuries.

Betting nugget: Read more about each team’s ATS records and betting trends.

Final score predictions: The experts say 49ers 27, Seahawks 14

FPI prediction: San Francisco will win by an average of 7 points.

Get ready for a thrilling day of Thanksgiving football with NFL Nation’s complete guide to the Week 12 matchups!


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