According to research conducted by the Public Health Agency of Canada (PHAC), a specific gene may be responsible for naturally reducing the viral loads of HIV in certain individuals. This gene, known as CHD1L, hinders HIV replication and transmission. The study, published in Nature, involved the collaboration of PHAC researchers and international partners. They analyzed the genetics of nearly 4,000 individuals of African ancestries who are living with HIV and found genetic variants that impact the CHD1L gene. The discovery of this new genetic variant is a significant breakthrough in HIV research and may pave the way for new treatment and prevention strategies. However, further research is needed to fully understand how this gene limits viral replication.
HIV is a sexually transmitted and blood-borne infection that attacks the body’s immune system, particularly T cells, which are crucial for fighting off infections. If left untreated, the virus weakens the immune system over time, making the individual more vulnerable to various infections and illnesses. Although there is no cure for HIV, significant progress has been made in managing the virus with antiretroviral therapy (ART).
In 2020, an estimated 1,520 new HIV infections occurred in Canada, slightly lower than the estimate for 2018, as reported by PHAC. This emphasizes the ongoing need for research and interventions to combat the virus.
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