Scientists at Ohio State University have discovered a link between two brain proteins, MAP6 and Kv3.1, which affects behaviour in mice. The researchers found the proteins, both known risk genes for schizophrenia, bond to each other under normal conditions in multiple parts of the brain, and that this connection is central to maintaining normal movement, memory and anxiety levels. If the proteins fail to connect correctly, behaviour can be negatively impacted. Disruption of the proteins’ interaction in mice led to increased hyperactivity, less risk avoidance and impaired memory. The next step is to examine how social behaviour in mice is impacted and explore new platforms for treatment.
Unlocking New Avenues for Schizophrenia Treatments through Brain Protein Bonding
