Mutation in DNA renders blood-thinner ineffective for numerous South Asian heart disease patients

  • Half of South Asians have a genetic mutation that renders clopidogrel ineffective
















Evidence suggests that a commonly prescribed blood-thinner, clopidogrel, may not be effective for individuals of South Asian descent.

Over half of individuals with Bangladeshi and Pakistani ancestry possess a genetic mutation that renders the drug ineffective.

Clopidogrel, also known as Plavix, is widely used by millions of Britons to prevent heart attacks and strokes. It acts by inhibiting blood cell adhesion, reducing the risk of clot formation.

Previous studies have shown that a significant proportion of the population does not respond to the medication due to a genetic mutation in the CYP2C19 gene, which is responsible for producing an enzyme that activates the drug in the liver.

Research involving European populations estimated that around a third of individuals are affected by this genetic mutation.

Mutation in DNA renders blood-thinner ineffective for numerous South Asian heart disease patients

More than half of those with Bangladeshi and Pakistani ancestry have a genetic mutation that stops the drug, clopidogrel, from working properly

Reference

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