According to a study conducted by US researchers, maintaining lean muscle mass through regular gym workouts can help stave off Alzheimer’s disease. The researchers analyzed data from 450,243 participants in the UK Biobank study and found that individuals with higher levels of lean muscle mass had a 12% lower risk of Alzheimer’s disease. Additionally, these individuals exhibited improved brain function in old age. Although obesity has been linked to a higher risk of Alzheimer’s, it remains unclear whether lower levels of lean muscle mass contribute to the disease. To investigate this further, the researchers used a genetic prediction technique called Mendelian randomization to gather data on the relationship between lean muscle and Alzheimer’s. By estimating lean muscle and fat tissue in the arms and legs while considering age, sex, and genetic ancestry, the researchers discovered that higher levels of lean muscle mass were associated with a modest reduction in Alzheimer’s risk. These findings were confirmed in a separate sample of individuals with and without Alzheimer’s, which used different measures of lean muscle mass. Interestingly, body fat was not associated with Alzheimer’s risk but was linked to poorer cognitive function. The study authors emphasize the need for further replication of their findings and suggest that future research should explore age and disease severity factors that may affect the impact of lean muscle mass on Alzheimer’s risk.
According to a separate study conducted by the University of Washington School of Medicine, global cases of dementia are expected to nearly triple by 2050. However, the rate of increase varies across regions, with Western Europe projected to see a 75% rise due to an aging population, North America expected to experience a doubling of cases, and North Africa and the Middle East anticipating a 375% increase. Alzheimer’s disease is the leading cause of dementia, and studies like the one on lean muscle mass’s impact on Alzheimer’s risk offer valuable insights in the fight against this debilitating illness. Currently, there is no cure for dementia, but early diagnosis and effective treatments can help slow its progression.
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