The Oct. 3 Health & Science article “Beating the rising costs of Rx drugs” offered useful personal strategies to mitigate rising prescription drug costs. However, systemic change is crucial for enduring reform that confronts Big Pharma profiteering, a driver of sky-high drug prices, and prioritizes public health. Temporary assistance programs serve merely as bandages, masking corporations’ unchecked authority to set inflated prescription drug costs and steering patients toward costlier brands. This profit-centric status quo is utterly unacceptable.