Fusobacterium, indicated by white dots, has been observed near the endometrium of endometriosis patients. The photo was taken by Professor Yutaka Kondo.
June 14 (UPI) — Japanese researchers have recently conducted a groundbreaking study that explores the potential of an antibiotic to reduce the lesions associated with endometriosis caused by Fusobacterium.
The study, conducted by a group affiliated with Nagoya University’s Graduate School of Medicine and iGCORE, was published in the prestigious journal Science Translational Medicine.
The findings of this research have the capacity to revolutionize the treatment and prevention of endometriosis-related lesions.
Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue, which is normally located inside the uterus, outside the organ.
About 1 in 10 women between the ages of 15 and 49 suffer from endometriosis, a condition that can have severe long-term consequences, including pelvic pain and infertility.
Current treatment methods for endometriosis involve hormone therapy and surgical resection. However, these procedures often carry significant side effects and may lead to recurrence, as well as impacting fertility.
In their collaboration with the National Cancer Center, the research group discovered that mice infected with Fusobacterium had more and heavier lesions in their uteruses. Conversely, the mice that were given an antibiotic to eradicate the bacteria showed improved lesion formation.
In the United States, Fusobacterium infections are typically treated with beta-lactam antibiotics, such as penicillin and cephalosporin.
Professor Yutaka Kondo, the leader of the study, stated, “This study demonstrated that the Fusobacterium-TAGLN-endometriosis axis is frequently dysregulated in endometriosis. Our data provide a strong and novel rationale for targeting Fusobacterium as a non-hormonal, antibiotic-based treatment for endometriosis.”
Furthermore, the researchers identified a protein called transgelin, also known as TAGLN, which is often upregulated in patients with endometriosis. This protein is associated with the development of the condition.
Kondo added, “Eradicating this bacterium through antibiotic treatment could be a potential approach to treating endometriosis in women who are positive for fusobacteria infection. Moreover, identifying such infection can be easily done through vaginal or uterus swabs.”
Denial of responsibility! VigourTimes is an automatic aggregator of Global media. In each content, the hyperlink to the primary source is specified. All trademarks belong to their rightful owners, and all materials to their authors. For any complaint, please reach us at – [email protected]. We will take necessary action within 24 hours.
